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J. Biochem, 2003, Vol. 133, No. 2 155-158
© 2003 Japanese Biochemical Society

JB MINIREVIEW

Discovery and Prospect of Protein Kinase C Research: Epilogue

Yasutomi Nishizuka+

Biosignal Research Center, Kobe University, Kobe 657-8501

Received January 9, 2003; accepted January 9, 2003

The first 150 words of the full text of this article appear below.

A tale of protein kinases

Biological materials containing phosphorus are the subject of renewed interest for biochemists since late in the 19th century. Pheobus Levene, who had been a pupil of the great German chemist Emil Fischer, working at the Rockefeller Institute for Medical Research, New York, found a class of acidic macromolecules present in the cell nucleus. This material, containing a large amount of phosphorus and nitrogen, was not nucleic acid that had been previously described by Friedrich Miescher. He called this material vitellin or paranucleic acid which, in retrospect, was a mixture of highly phosphorylated transcription factors and other nuclear proteins. In 1932, he and Fritz Lipmann found that the phosphate was covalently attached to serine residues of the proteins (1). At this time they anticipated if the serine-phosphate could be a storage form of high energy phosphate bounds. Several decades later, enzymes capable of adding phosphate from ATP to phosvitin . . . [Full Text of this Article]

Lessons from protein kinases A and G

Discovery of protein kinase C

Diacylglycerol as signal mediator

Phorbol ester and cell signaling

Molecular heterogeneity and mode of activation

Targeting and multiple lipid mediators

Coda


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