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J. Biochem, 2003, Vol. 134, No. 3 305-307
© 2003 Japanese Biochemical Society

JB MINIREVIEWS

Signal Transduction Underlying Cell Morphogenesis: Editorial Overview

Shuh Narumiya*

Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606-8501

Received August 20, 2003; accepted August 22, 2003

Key words: actin cytoskeleton, microtubules, cell-substrate adhesion, cell-cell adhesion, cell polarity, spatial cues.

The first 150 words of the full text of this article appear below.

Cells adopt various types of morphology depending on their environment. For example, they change shape in response to extracellular stimuli, during progression through the cell cycle, or on contact with or isolation from other cells in culture or in situ. Cell morphology is determined primarily by the cytoskeleton, especially the actin cytoskeleton and microtubules, and by adhesion contacts. Basic mechanisms for assembly of the cytoskeleton and for cell adhesion, as well as the signaling pathways and molecules that regulate these processes, have recently begun to be revealed. This Minireview series, consisting of 10 articles, is intended to highlight this recent progress in order to provide insight into the molecular events that underlie cell morphogenesis. It also addresses the prospects for future studies in this exciting field. This editorial overview provides some background to the articles that follow.

Actin dynamics and Rho GTPase signaling

Assembly of the actin cytoskeleton begins with the nucleation and polymerization of actin . . . [Full Text of this Article]

Microtubules: dynamic instability and selective stabilization

Septins: a fourth type of cytoskeleton

Cell-substrate adhesion versus cell-cell adhesion

Spatial cues for cell morphogenesis in tissues

Conclusions


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