Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Takita, M.
Right arrow Articles by Ogura, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takita, M.
Right arrow Articles by Ogura, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

J. Biochem, 1988, Vol. 103, No. 5 778-786
© 1988 Japanese Biochemical Society

research-article

Effect of Bile Duct Ligation on Bile Acid and Cholesterol Metabolism in Rats

Minoru Takita*, Shiro Ikawa* and Yoshio Ogura**

* Division of Chemistry, Institute of Steroid Research, Tottori University School of Medicine Yonago, Tottori 683
** Department of Biochemistry, Tottori University School of Medicine Yonago, Tottori 683

The effects of bile duct ligation on bile acid and cholesterol metabolism were examined in male Wistar strain rats. Quantitative and qualitative changes of bile acids and cholesterol in serum and urine occurred; ß-muricholic acid predominantly increased in serum and urine and the ratio of urinary cholic acid and ß-muricholic acid changed from about 5 : 3 on day 1 to about 1 : 8 on day 5 under biliary obstruction. The form of the increased urinary bile acids was mainly taurine-conjugated and partly sulfated. Under conditions of bile duct ligation on day 5, 14C-labeled 3ß-hydroxy-5-cholenoic, lithocholic, and chenodeoxycholic acids were intragastrically administered to the rats after pretreatment with antibiotics and the metabolites of these three acids were investigated. 3ß-Hydroxy-5-cholenoic acid was most efficiently converted to ß-muricholic acid. The present study strongly suggested the presence of an alternative metabolic pathway induced by bile duct ligation, which caused the change in composition of urinary bile acids, and especially the marked increase in ß-muricholic acid formation. A possible alternative pathway for bile acid biosynthesis under biliary obstruction in rats is postulated.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
Y. Alnouti
Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification
Toxicol. Sci., April 1, 2009; 108(2): 225 - 246.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Stedman, G. Robertson, S. Coulter, and C. Liddle
Feed-forward Regulation of Bile Acid Detoxification by CYP3A4: STUDIES IN HUMANIZED TRANSGENIC MICE
J. Biol. Chem., March 19, 2004; 279(12): 11336 - 11343.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Mesotten, G. Van den Berghe, C. Liddle, S. Coulter, F. McDougall, R. C. Baxter, and P. J. D. Delhanty
Growth Hormone Modulation of the Rat Hepatic Bile Transporter System in Endotoxin-Induced Cholestasis
Endocrinology, September 1, 2003; 144(9): 4008 - 4017.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. K. Spady, J. A. Cuthbert, M. N. Willard, and R. S. Meidell
Feedback Regulation of Hepatic 7alpha -Hydroxylase Expression by Bile Salts in the Hamster
J. Biol. Chem., August 2, 1996; 271(31): 18623 - 18631.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.