J. Biochem, 1995, Vol. 118, No. 3 643-649
© 1995 Japanese Biochemical Society
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Hepatocyte Growth Factor Suppresses the Onset of Liver Cirrhosis and Abrogates Lethal Hepatic Dysfunction in Rats1
*Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Medical School Suita, Osaka 565
Third Department of Internal Medicine, Niigata University Medical School Niigata, Niigata 951
2To whom correspondence should be addressed. Tel: +81-6-879-3783, Fax: +81-6-879-3789
Hepatic fibrosis/cirrhosis is a common hepatic disease characterized by the hyper-accumulation of connective tissue components, and hepatic necrosis. Chronic alcohol inges-tion, viral infection, and metabolic disorders are contributing factors and there has been no effective treatment. Hepatocyte growth factor (HGF), originally identified as a potent mitogen for mature hepatocytes, is a long-sought hepatotrophic factor for liver regeneration. Administration of human recombinant HGF into rats with hepatic fibrosis/cirrhosis caused by dimethylnitrosamine (DMN) elicited mitogenic action for hepatocytes, stimulated hepatic collagenase activity, and prevented the onset and progression of hepatic fibrosis/cirrhosis. Accumulation of fibrous tissue components in the liver due to DMN-treatment were markedly decreased in HGF-injected rats. Moreover, HGF completely abrogated death caused by severe hepatic cirrhosis and dysfunction. We postulate that HGF may prove to be an effective treatment for human liver fibrosis/cirrhosis and for chronic hepatic failure.
1This work was supported by a Research Grant for Science and Cancer from the Ministry of Education, Science and Culture of Japan.
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