J. Biochem, 1996, Vol. 120, No. 4 803-812
© 1996 Japanese Biochemical Society
other |
Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma
*Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University 1–5–8 Hatanodai, Shinagawa-ku, Tokyo 142
Japanese Red Cross Tokyo Blood Center Sakaiminami-cho, Musashino, Tokyo 180
1To whom correspondence should be addressed. Phone: +81.3.3784.8215, Fax: +81-3-3784-8216, E-mail: yanakano{at}pahrma.showa-u.ac.jp
By use of its affinity to gelatin-Cellulofine, a novel protein, GBP28 (gelatin-binding protein of 28 kDa), was obtained from human plasma. GBP28 bound to gelatin-Cellulofine could be eluted with 1 M NaCl. By analysis of its amino-terminal amino acid sequences and the peptides obtained by protease digestion, GBP28 was identified as a novel protein. After repeated gel chromatography of the 1 M NaCl eluate from gelatin-Cellulofine, about 50 µg of GBP28 was purified from 500 ml of human plasma. On gel chromatography, the protein migrated as a molecule of about 420 kDa. On SDS-PAGE, its molecular mass was 28 kDa under reducing conditions and 68 kDa under nonreducing conditions. Recently, human mRNA specific to adipose tissue, cDNA clone apM1, has been registered [Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., and Matsubara, K. (1996) Biochem. Biophys. Res. Commun. 221, 286–289]. The assumed amino acid sequence of cDNA clone apM1 contained all the sequences of GBP28 and its peptides. Therefore, it is evident that the cDNA clone apM1 encodes GBP28 and the protein is specific to adipose tissue. The clone encodes a polypeptide of 244 amino acids with a secretory signal sequence at the amino terminus, a small non-helical region, a stretch of 22 collagen repeats and a globular domain. Thus, GBP28 appears to belong to a family of proteins possessing a collagen-like domain through which they form homo-trimers, which further combine to make oligomeric complexes. Although its biological function is presently unclear, its adipocyte-specific expression suggests that GBP28 may function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism.
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P. J. Havel Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism Diabetes, February 1, 2004; 53(90001): S143 - 151. [Abstract] [Full Text]
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E. Sivan, S. Mazaki-Tovi, C. Pariente, Y. Efraty, E. Schiff, R. Hemi, and H. Kanety Adiponectin in Human Cord Blood: Relation to Fetal Birth Weight and Gender J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5656 - 5660. [Abstract] [Full Text] [PDF]
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Y.-M. Liu, J.-M. Lacorte, N. Viguerie, C. Poitou, V. Pelloux, B. Guy-Grand, C. Coussieu, D. Langin, A. Basdevant, and K. Clement Adiponectin Gene Expression in Subcutaneous Adipose Tissue of Obese Women in Response to Short-Term Very Low Calorie Diet and Refeeding J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5881 - 5886. [Abstract] [Full Text] [PDF]
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 Y. Miyoshi, T. Funahashi, S. Kihara, T. Taguchi, Y. Tamaki, Y. Matsuzawa, and S. Noguchi Association of Serum Adiponectin Levels with Breast Cancer Risk Clin. Cancer Res., November 15, 2003; 9(15): 5699 - 5704. [Abstract] [Full Text] [PDF]
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T. Yokota, C. S. R. Meka, T. Kouro, K. L. Medina, H. Igarashi, M. Takahashi, K. Oritani, T. Funahashi, Y. Tomiyama, Y. Matsuzawa, et al. Adiponectin, a Fat Cell Product, Influences the Earliest Lymphocyte Precursors in Bone Marrow Cultures by Activation of the Cyclooxygenase-Prostaglandin Pathway in Stromal Cells J. Immunol., November 15, 2003; 171(10): 5091 - 5099. [Abstract] [Full Text] [PDF]
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H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M. J. Quon Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells J. Biol. Chem., November 7, 2003; 278(45): 45021 - 45026. [Abstract] [Full Text] [PDF]
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 T. Kadowaki, K. Hara, T. Yamauchi, Y. Terauchi, K. Tobe, and R. Nagai Molecular Mechanism of Insulin Resistance and Obesity Experimental Biology and Medicine, November 1, 2003; 228(10): 1111 - 1117. [Abstract] [Full Text] [PDF]
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H. Waki, T. Yamauchi, J. Kamon, Y. Ito, S. Uchida, S. Kita, K. Hara, Y. Hada, F. Vasseur, P. Froguel, et al. Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes: MOLECULAR STRUCTURE AND MULTIMER FORMATION OF ADIPONECTIN J. Biol. Chem., October 10, 2003; 278(41): 40352 - 40363. [Abstract] [Full Text] [PDF]
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A. S. Ryan, D. M. Berman, B. J. Nicklas, M. Sinha, R. L. Gingerich, G. S. Meneilly, J. M. Egan, and D. Elahi Plasma Adiponectin and Leptin Levels, Body Composition, and Glucose Utilization in Adult Women With Wide Ranges of Age and Obesity Diabetes Care, August 1, 2003; 26(8): 2383 - 2388. [Abstract] [Full Text] [PDF]
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M. Chandran, S. A. Phillips, T. Ciaraldi, and R. R. Henry Adiponectin: More Than Just Another Fat Cell Hormone? Diabetes Care, August 1, 2003; 26(8): 2442 - 2450. [Full Text] [PDF]
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T. Gohda, Y. Makita, T. Shike, M. Tanimoto, K. Funabiki, S. Horikoshi, and Y. Tomino Identification of Epistatic Interaction Involved in Obesity Using the KK/Ta Mouse as a Type 2 Diabetes Model: Is Zn-{alpha}2 Glycoprotein-1 a Candidate Gene for Obesity? Diabetes, August 1, 2003; 52(8): 2175 - 2181. [Abstract] [Full Text] [PDF]
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M. Furuhashi, N. Ura, K. Higashiura, H. Murakami, M. Tanaka, N. Moniwa, D. Yoshida, and K. Shimamoto Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension Hypertension, July 1, 2003; 42(1): 76 - 81. [Abstract] [Full Text] [PDF]
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J. Krakoff, T. Funahashi, C. D.A. Stehouwer, C. G. Schalkwijk, S. Tanaka, Y. Matsuzawa, S. Kobes, P. A. Tataranni, R. L. Hanson, W. C. Knowler, et al. Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian Diabetes Care, June 1, 2003; 26(6): 1745 - 1751. [Abstract] [Full Text] [PDF]
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M. K. S. Leow, C. L. Addy, and C. S. Mantzoros Human Immunodeficiency Virus/Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome: Clinical Presentation, Pathophysiology, and Therapeutic Strategies J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 1961 - 1976. [Full Text] [PDF]
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Q. Tong, J.-L. Sankale, C. M. Hadigan, G. Tan, E. S. Rosenberg, P. J. Kanki, S. K. Grinspoon, and G. S. Hotamisligil Regulation of Adiponectin in Human Immunodeficiency Virus-Infected Patients: Relationship to Body Composition and Metabolic Indices J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1559 - 1564. [Abstract] [Full Text] [PDF]
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 T. Pischon, G. S. Hotamisligil, and E. B. Rimm Adiponectin: Stability in Plasma over 36 Hours and Within-Person Variation over 1 Year Clin. Chem., April 1, 2003; 49(4): 650 - 652. [Full Text] [PDF]
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 M. Bensaid, M. Gary-Bobo, A. Esclangon, J. P. Maffrand, G. Le Fur, F. Oury-Donat, and P. Soubrie The Cannabinoid CB1 Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells Mol. Pharmacol., April 1, 2003; 63(4): 908 - 914. [Abstract] [Full Text] [PDF]
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U. B. Pajvani, X. Du, T. P. Combs, A. H. Berg, M. W. Rajala, T. Schulthess, J. Engel, M. Brownlee, and P. E. Scherer Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin. IMPLICATIONS FOR METABOLIC REGULATION AND BIOACTIVITY J. Biol. Chem., March 7, 2003; 278(11): 9073 - 9085. [Abstract] [Full Text] [PDF]
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E. Petridou, C. Mantzoros, N. Dessypris, P. Koukoulomatis, C. Addy, Z. Voulgaris, G. Chrousos, and D. Trichopoulos Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case-Control Study in Greece J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 993 - 997. [Abstract] [Full Text] [PDF]
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S. A. Phillips, T. P. Ciaraldi, A. P.S. Kong, R. Bandukwala, V. Aroda, L. Carter, S. Baxi, S. R. Mudaliar, and R. R. Henry Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy Diabetes, March 1, 2003; 52(3): 667 - 674. [Abstract] [Full Text] [PDF]
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C. L. Addy, A. Gavrila, S. Tsiodras, K. Brodovicz, A. W. Karchmer, and C. S. Mantzoros Hypoadiponectinemia Is Associated with Insulin Resistance, Hypertriglyceridemia, and Fat Redistribution in Human Immunodeficiency Virus-Infected Patients Treated with Highly Active Antiretroviral Therapy J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 627 - 636. [Abstract] [Full Text] [PDF]
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 A. S. Lihn, T. Ostergard, B. Nyholm, S. B. Pedersen, B. Richelsen, and O. Schmitz Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E443 - E448. [Abstract] [Full Text] [PDF]
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H. Makimura, T. M. Mizuno, H. Bergen, and C. V. Mobbs Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1266 - E1271. [Abstract] [Full Text] [PDF]
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M. W. Hulver, D. Zheng, C. J. Tanner, J. A. Houmard, W. E. Kraus, C. A. Slentz, M. K. Sinha, W. J. Pories, K. G. MacDonald, and G. L. Dohm Adiponectin is not altered with exercise training despite enhanced insulin action Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E861 - E865. [Abstract] [Full Text] [PDF]
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T.-S. Tsao, H. E. Murrey, C. Hug, D. H. Lee, and H. F. Lodish Oligomerization State-dependent Activation of NF-kappa B Signaling Pathway by Adipocyte Complement-related Protein of 30 kDa (Acrp30) J. Biol. Chem., August 9, 2002; 277(33): 29359 - 29362. [Abstract] [Full Text] [PDF]
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C. Menzaghi, T. Ercolino, R. Di Paola, A. H. Berg, J. H. Warram, P. E. Scherer, V. Trischitta, and A. Doria A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome Diabetes, July 1, 2002; 51(7): 2306 - 2312. [Abstract] [Full Text] [PDF]
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H. Kondo, I. Shimomura, Y. Matsukawa, M. Kumada, M. Takahashi, M. Matsuda, N. Ouchi, S. Kihara, T. Kawamoto, S. Sumitsuji, et al. Association of Adiponectin Mutation With Type 2 Diabetes : A Candidate Gene for the Insulin Resistance Syndrome Diabetes, July 1, 2002; 51(7): 2325 - 2328. [Abstract] [Full Text] [PDF]
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M. Matsubara, S. Maruoka, and S. Katayose Decreased Plasma Adiponectin Concentrations in Women with Dyslipidemia J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2764 - 2769. [Abstract] [Full Text] [PDF]
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