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J. Biochem, 2003, Vol. 134, No. 5 759-764
© 2003 Japanese Biochemical Society

CELL

Cellular Requirements for CRM1 Import and Export

Xianfeng Zhang, Masami Yamada*, Naoto Mabuchi§ and Hisatoshi Shida

Department of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, Hokkaido 060-0815

We studied the cellular requirements for the translocation of CRM1 (exportin 1) between the nucleus and the cytoplasm. CRM1 import requires neither ATP, Ran, Ran-dependent GTP hydrolysis, nor a particular temperature. CRM1 and importin ß compete with each other during their import. Thus, CRM1 is able to enter the nucleus in a manner similar to importinß. In contrast, the in vivo export of CRM1 involves ATP-consuming step(s).

* Present address: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

§ Present address: Institute for Virus Research, Kyoto University, Kyoto 606-8507.

To whom correspondence should be addressed. Tel/Fax: +81-11-706-7543, E-mail: hshida{at}imm.hokudai.ac.jp


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