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J. Biochem, 2004, Vol. 136, No. 3 279-282
© 2004 The Japanese Biochemical Society

CELL

Abundant Retention and Release of Connective Tissue Growth Factor (CTGF/CCN2) by Platelets

Satoshi Kubota1,2, Kazumi Kawata1,2, Takeshi Yanagita1,2, Hideyuki Doi1,2, Takashi Kitoh1,2 and Masaharu Takigawa1,2,*

1 Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8525; and 2 Biosciences Research & Development Center, Nichirei Corporation, Tokyo 180-0003

Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of the major functional components of platelets.

* To whom correspondence should be addressed. Tel: +81-86-235-6646, Fax: +81-86-235-6649, E-mail: takigawa{at}md.okayama-u.ac.jp


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