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Journal of Biochemistry Advance Access originally published online on December 11, 2006
Journal of Biochemistry 2007 141(1):113-119; doi:10.1093/jb/mvm012
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© 2006 The Japanese Biochemical Society.

Transient Expression of Bone Morphogenic Protein-2 in Acute Liver Injury by Carbon Tetrachloride

Ryusuke Nakatsuka1, Makoto Taniguchi1, Mitsuhi Hirata1, Goshi Shiota2 and Kenzo Sato1,*

1Division of Molecular Biology, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine; and 2Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago 683-8503, Japan

*To whom correspondence should be addressed at: Kenzo Sato, Department of Molecular and Cellular Biology, School of Life Sciences, Tottori University Faculty of Medicine, 86 Nishi-cho, Yonago 683-8503 Japan. Tel: +81-859-38-6201, Fax: +81-859-38-6200, E-mail: kensato{at}grape.med.tottori-u.ac.jp

Received September 20, 2006; Accepted November 21, 2006


  Abstract

Acute liver injury induced by administration of carbon tetrachloride (CCl4) was shown to be a model of wound-repair in rat liver. Albumin gene expression was significantly reduced at 24 h post injection with CCl4, but recovered at 48 h. We also observed significant and transient expression of bone morphogenic protein-2 (BMP-2) at 6-24 h post treatment. This expression was also shown with depletion of Kupffer cell by GdCl3, and immunostaining with anti-BMP-2 antibody showed BMP-2-producing cells interspersed in intralobular spaces of injured liver. These observations suggest that BMP-2 secreted from oval-like cells plays important roles in the wound healing response of injured liver.

Key Words: BMP-2, carbon tetrachloride, gene expression, liver injury, wound-repair response


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