Skip Navigation


Journal of Biochemistry Advance Access originally published online on April 3, 2007
Journal of Biochemistry 2007 141(5):609-614; doi:10.1093/jb/mvm091
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
141/5/609    most recent
mvm091v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Ito, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ito, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 The Japanese Biochemical Society.

JB Minireviews-Genome Decoding Systems

Role of Histone Modification in Chromatin Dynamics

Takashi Ito

Department of Biochemistry, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan

To whom correspondence should be addressed. Tel: +81-95-849-7037, Fax: +81-95-849-7040, E-mail: tito{at}net.nagasaki-u.ac.jp

Received September 25, 2006; Accepted March 25, 2007


  Abstract

The covalent modification of histone tails has emerged as a crucial step in controlling the eucaryotic genomes. Eucaryotic cells must possess mechanisms for condensing and decondensing chromatin. Moreover, chromatin condensation is particularly evident during mitosis and apoptotic cell death, whereas chromatin relaxation is necessary for replication, repair, recombination and transcription. The post-translational modifications of histone tails such as reversible acetylation, phosphorylation and methylation play a critical role in dynamic condensation/relaxation that occurs during the cell cycle. Histone phosphorylation is believed to play a direct role in mitosis, cell death, repair, replication and recombination. In this review, we discuss recent progress in studies of histone phosphorylation.

Key Words: chromatin, histone code, NHK-1, nucleosome, modification, transcription


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. N. Iberg, A. Espejo, D. Cheng, D. Kim, J. Michaud-Levesque, S. Richard, and M. T. Bedford
Arginine Methylation of the Histone H3 Tail Impedes Effector Binding
J. Biol. Chem., February 8, 2008; 283(6): 3006 - 3010.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Grau, C. Popescu, L. Torroja, D. Ortuno-Sahagun, I. Boros, and A. Ferrus
Transcriptional Adaptor ADA3 of Drosophila melanogaster Is Required for Histone Modification, Position Effect Variegation, and Transcription
Mol. Cell. Biol., January 1, 2008; 28(1): 376 - 385.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.