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Journal of Biochemistry Advance Access originally published online on March 4, 2007
Journal of Biochemistry 2007 141(5):669-674; doi:10.1093/jb/mvm069
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© 2007 The Japanese Biochemical Society.

Effects of Triethylene Tetraamine on the G-quadruplex Structure in the Human c-myc Promoter

Fei Yin1,2, Jianhui Liu1,*, Xiaohong Deng1 and Jingyun Wang3

1Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University; 2College of Environment and Bioengineering, Chongqing Technology and Business University, Chongqing 400067, China; and 3College of Environment and Bioengineering, Dalian University of Technology, Dalian 116023, China

*To whom correspondence should be addressed. Tel: 86-23-6276-9652, Fax: 86-23-6276-9652, E-mail: jhliu{at}dlut.edu.cn

Received February 8, 2007; Accepted February 22, 2007


  Abstract

The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III1 (NHE III1) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III1 element, and inhibits the expression of c-myc in HeLa cells.

Key Words: c-Myc, G-quadruplex, telomerase, triethylene tetraamine

Abbreviations: TETA, triethylene tetraamine; CD, circular dichroism; NHE, nuclease-hypersensitivity element


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