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Journal of Biochemistry Advance Access originally published online on November 12, 2007
Journal of Biochemistry 2008 143(2):155-161; doi:10.1093/jb/mvm219
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© 2007 The Japanese Biochemical Society.

JB Minireviews-Functional Dynamics of the Nucleus

Till Disassembly Do Us Part: A Happy Marriage of Nuclear Envelope and Chromatin

Yuichi Tsuchiya*

Department of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540 Japan

*To whom correspondence should be addressed. Tel: +81-3-3762-4151 ext. 2356, Fax: +81-3-5493-5412, E-mail: tsuchiya{at}med.toho-u.ac.jp

Received September 28, 2007; Accepted October 12, 2007


  Abstract

A characteristic feature of eukaryotic cells is the presence of nuclear envelope (NE) which separates genomic DNA from cytoplasm. NE is composed of inner nuclear membrane (INM), which interacts with chromatin, and outer nuclear membrane, which is connected to endoplasmic reticulum. Nuclear pore complexes are inserted into NE to form transport channels between nucleus and cytoplasm. In metazoan cells, an intermediate filament-based meshwork called as nuclear lamina exists between INM and chromatin. Sophisticated collaboration of these molecular machineries is necessary for the structure and functions of NE. Recent research advances have revealed that NE dynamically communicates with chromatin and cytoskeleton to control multiple nuclear functions. In this mini review, I briefly summarize the basic concepts and current topics of functional relationships between NE and chromatin.

Key Words: chromatin, lamin, nuclear envelope, nuclear membrane, nucleus

Abbreviations: BAF, barrier-to-autointegration factor; ER, endoplasmic reticulum; HIV-1, human immunodeficiency virus 1; INM, inner nuclear membrane; LAP2, lamina-associated polypeptide 2; LBR, lamin B receptor; MoMLV, Moloney murine leukaemia virus; NE, nuclear envelope; NPC, nuclear pore complex; ONM, outer nuclear membrane; PIC, preintegration complex


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