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J. Biochem, 1984, Vol. 95, No. 2 503-510
© 1984 Japanese Biochemical Society

research-article

Nature of the Binding Site Around and Reactivity of Histidine-15 in Lysozyme

Hidenori YAMADA, Futoshi UOZUMI, Atsuko ISHIKAWA and Taiji IMOTO

Faculty of Pharmaceutical Sciences, Kyushu University 62 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812

Bromoacetamide derivatives having n-alkyl substituents (BrCH2CONH(CH2)nH, 1-n) and carboxyalkyl substituents (BrCH2CONH(CH2)nCOOH, 2-n) react with His-15 in lysozyme exclusively at N2 at pH 5.5 and 40°C. Kinetic studies suggest that lysozyme has a small hydrophobic pocket that binds these reagents in the vicinity of His-15.


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