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Journal of Biochemistry Advance Access published online on December 11, 2006
Journal of Biochemistry, doi:10.1093/jb/mvm012
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© 2006 The Japanese Biochemical Society

Transient Expression of Bone Morphogenic Protein-2 in Acute Liver Injury by Carbon Tetrachloride

Ryusuke Nakatsuka1, Makoto Taniguchi1, Mitsuhi Hirata1, Goshi Shiota2 and Kenzo Sato1,*

1Division of Molecular Biology, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, and 2Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago 683-8503, Japan.

*To whom correspondence should be addressed: Kenzo Sato, Department of Molecular and Cellular Biology, School of Life Sciences, Tottori University Faculty of Medicine, 86 Nishi-cho, Yonago 683-8503 Japan, Fax: +81-859-38-6200, E-mail: kensato{at}grape.med.tottori-u.ac.jp


  Abstract

Acute liver injury induced by administration of carbon tetrachloride (CCl4) was shown to be a model of wound-repair in rat liver. Albumin gene expression was significantly reduced at 24 hr post injection with CCl4, but recovered at 48 hr. We also observed significant and transient expression of bone morphogenic protein-2 (BMP-2) at 6-24 hr post treatment. This expression was also shown with depletion of Kupffer cell by GdCl3, and immunostaining with anti-BMP-2 antibody showed BMP-2-producing cells interspersed in intralobular spaces of injured liver. These observations suggest that BMP-2 secreted from oval-like cells plays important roles in the wound healing response of injured liver.

Key Words: BMP-2, carbon tetrachloride, Gene expression, Liver injury, wound-repair response


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