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Journal of Biochemistry Advance Access published online on February 21, 2007
Journal of Biochemistry, doi:10.1093/jb/mvm061
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© 2007 The Japanese Biochemical Society

JB Review

Regulation of Wnt Signaling by Receptor-mediated Endocytosis

Akira Kikuchi* and Hideki Yamamoto

Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

*Corresponding author. Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan, Tel: 81-82-257-5130; Fax: 81-82-257-5134; e-mail: akikuchi{at}hiroshima-u.ac.jp

Received February 1, 2007; Accepted February 13, 2007


  Abstract

Wnts compromise a large family of secreted and hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms. Recent advances in the field of Wnt signaling have revealed that Wnt activates multiple intracellular cascades, resulting in the regulation of cellular proliferation, differentiation, migration, and polarity. However, it is not clear how Wnt activates these pathways after it binds to the receptors. It has been shown that Wnt and its antagonist Dickkopf are internalized with their receptors. This review highlights distinct endocytic pathways correlate with specificity of Wnt signaling events.

Key Words: Wnt, low-density-lipoprotein receptor-related protein 5/6, Frizzled, post-translational modification, endocytosis


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