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Journal of Biochemistry Advance Access published online on March 4, 2007
Journal of Biochemistry, doi:10.1093/jb/mvm069
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© 2007 The Japanese Biochemical Society

Effects of Triethylene Tetraamine on the G-quadruplex Structure in the Human c-myc Promoter

Fei Yin1,2, Jianhui Liu1,*, Xiaohong Deng1 and Jingyun Wang3

1, Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University, Chongqing, 400067, China
2, College of Environment and Bioengineering, Chongqing Technology and Business University, Chongqing, 400067, China
3, College of Environment and Bioengineering, Dalian University of Technology, Dalian, 116023, China

*, To whom Correspondence should be: Tel/Fax: 86-23-6276-9652; E-mail: jhliu{at}dlut.edu.cn; Address: Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University, Chongqing, 400067, China

Received February 8, 2007; Accepted February 22, 2007


  Abstract

The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III1 (NHE III1) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has been exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III1 element, and inhibits the expression of c-myc in HeLa cells.

Key Words: Triethylene tetraamine, G-quadruplex, c-Myc, Telomerase


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