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Journal of Biochemistry Advance Access published online on January 7, 2008
Journal of Biochemistry, doi:10.1093/jb/mvm248
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© 2008 The Japanese Biochemical Society

Annexin A3 Expression Increases in Hepatocytes and is Regulated by Hepatocyte Growth Factor in Rat Liver Regeneration

Mizuho Harashima1, Kayo Harada1, Yoshimasa Ito1, Masashi Hyuga2, Taiichiro Seki1, Toyohiko Ariga1, Teruhide Yamaguchi2 and Shingo Niimi2,*

1 Department of Nutrition and Physiology, Nihon University College of Bioresource Sciences, Kameino Fujisawa 252-8510: and 2Division of Biological Chemistry and Biologicals, National Institute of Health Sciences,1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan

*To whom correspondence should be addressed: Dr. Niimi Shingo: Tel: +81-3-3700-9347, Fax: +81-3-3700-9084, E-mail: niimi{at}nihs.go.jp

Received November 14, 2007; Accepted December 18, 2007


  Abstract

Annexin (Anx) A3 increases and plays important roles in the signaling cascade in hepatocyte growth in cultured hepatocytes. However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the signaling cascade in rat liver regeneration. AnxA3 protein and mRNA level both increase in liver after administration of carbon tetrachloride (CCl4) or 70% partial hepatectomy. AnxA3 protein level increases in isolated parenchymal hepatocytes, but not in non-parenchymal liver cells in these rat liver regeneration models. AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level. These results demonstrate that AnxA3 expression increases in hepatocytes through a hepatocyte growth factor-mediated pathway in rat liver regeneration models, suggesting that AnxA3 plays an important role in the signaling cascade in rat liver regeneration.

Key Words: partial hepatectomy, carbon tetrachloride, parenchymal hepatocytes, annexin A3, hepatocyte growth factor


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